Potential new eye tumor treatment discovered

ScienceDaily (Aug. 4, 2011) ? New research from a team including several Carnegie scientists demonstrates that a specific small segment of RNA could play a key role in the growth of a type of malignant childhood eye tumor called retinoblastoma. The tumor is associated with mutations of a protein called Rb, or retinoblastoma protein. Dysfunctional Rb is also involved with other types of cancers, including lung, brain, breast and bone.

Their work, which will be the cover story of the August 15th issue of Genes & Development, could result in a new therapeutic target for treating this rare form of cancer and potentially other cancers as well.

MicroRNAs are a short, single strands of genetic material that bind to longer strands of messenger RNA--which is the courier that brings the genetic code from the DNA in the nucleus to the cell's ribosome, where it is translated into protein. This binding activity allows microRNAs to silence the expression of select genes in a targeted manner. Abnormal versions of microRNAs have been implicated in the growth of several types of cancer.

The paper from Carnegie's Karina Conkrite, Maggie Sundby and David MacPherson--as well as authors from other institutions -- focuses on a cluster of microRNAs called miR-17~92. Recent research has shown that aberrant versions of this cluster are involved in preventing pre-cancerous cells from dying and allowing them to proliferate into tumors. Previous work has shown that miR-17~92 can be involved in the survival of lymphoma and leukemia cells by reducing the levels of a tumor-suppressing protein called PTEN.

The team's new research shows that miR-17~92 can also be involved in retinoblastoma, although it does not act in the same way, via the PTEN protein, as it does in other types of cancers. Rather, miR-17~92 acts to help cells that lack the tumor-suppressing Rb protein to proliferate.

First the team demonstrated that miR-17~92 is expressed in higher-than-usual quantities in all human retinoblastomas examined and in some mouse retinoblastomas. The authors engineered mice to express high levels of miR-17~92 in their retinas. When coupled with inactivation of Rb family members, expression of miR-17~92 led to extremely rapid and aggressive retinoblastoma. Then they showed that this abundance of miR-17~92 acts to suppress an inhibitor of proliferation, called p21Cip1, which is supposed to compensate for the loss of Rb.

"These findings -- which show that miR-17~92 overcomes the cell's attempts to compensate for the loss of Rb -- could be similar in other types of cancers," MacPherson said. "This microRNA cluster could represent a new therapeutic target for treating tumors caused by Rb deficiency."

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The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by Carnegie Institution.

Journal Reference:

  1. Karina Conkrite, Maggie Sundby, Shizuo Mukai, J. Michael Thomson, David Mu, Scott M. Hammond, and David MacPherson. miR-17?92 cooperates with RB pathway mutations to promote retinoblastoma. Genes & Development, August 4, 2011 DOI: 10.1101/gad.17027411

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2011/08/110804170041.htm

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Sports: SK Gaming and Bigben at gamescom 2011 | SK Gaming

In only 2 weeks the biggest computer games trade fair will be hosted again in Cologne, Germany. This big event is representative of the whole gaming industry, also for our partner BigBen Interactive. Like the last years we will have our own booth in cooperation with Bigben Interactive. As always there will be games, activities and prizes.

A lot of SK players will be in Cologne so you can ask them things you ever wanted to know and play against them.

Where I can find the booth and when can I meet some players?

You can find our booth at Hall 6.1, boothnumber B040 form Wednesday up to Sunday evening and you will find SK guys around all the time.

What has the booth to offer?

We will be holding the only eSports-Olypmpics on GamesCom. So if you realy want to win some prizes and know what's going on, come see us!

We are looking forward to see you at this year's GamesCom.

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Some additional informations:

Opening hours for visitors (Hall 6-10):

Thursday, 18.08.2011 10:00-20:00
Friday, 19.08.2011 10:00-20:00
Saturday, 20.08.2011 09:00-20:00
Sunday, 21.08.2011 09:00-18:00

Source: http://www.sk-gaming.com/content/34060-SK_Gaming_and_Bigben_at_gamescom_2011

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Look No Further Than Home Depot For Appliances ? All Your Home ...

No matter what store you buy your home appliance from, you will pay about the same price. And the warranty is the same everywhere. After all, it is a factory warranty, not a store warranty. So, if the price is about the same, why buy from any particular store?

Because there is one store that gives the best customer service, and often, the best price. Home Depot was founded in 1978 and is the worlds largest home improvement specialty retailer. It is the second largest retailer in the United States, second only to Wal-Mart.

Home Depot goes the extra mile not only to get your business, but to help you in all your home improvement projects. Every week they conduct in-store clinics open to everyone. And don?t worry about not understanding or not being able to follow along. The instructors will make sure everyone understands by using easy-to-follow instructions. And if you don?t understand, ask the instructor to go back over the part you didn?t understand. They won?t mind.

Would you like to attend the workshop but have time constraints? No problem. Sit on the couch with your laptop in front of you, or sit in front of the home computer and check out the online workshops. They have thirty minute lessons that cover a wide range of home improvement topics. And they have a workshop archive of home improvements that will help you with almost any home project.

Home Depot is the only home improvement retailer to teach do-it-yourself skills and tool safety to children. If you have a son or daughter 5-12 years old, once a month they will be able to attend one of these workshops. And all these workshops are FREE!

Want more reasons to shop Home Depot? How about Home Depot appliances? You will find all the name brand appliances you know, love and trust. Whether you want Maytag, Westinghouse, Norge, GE, LG, Whirlpool, etc., Home Depot has them all. And they have them in a variety of colors.

Another reason to shop for Home Depot appliances is the price. They offer store discounts that often gives you a cheaper price for name brand merchandise. On top of that you get the best customer service in the industry.

The best reason to come to Home Depot is that you?ll be able to do all your home improvement shopping under one roof. Besides Home Depot appliances, you?ll find toilets, whirlpools, tubs, showers, vanities, lumber, ladders, fireplaces, hearths, windows, doors, drywall, furniture, electronics, paint, plumbing, grills and almost anything you need for the home. And you?ll even find the tools you need to complete any home improvement project.

If Home Depot appliances are the only reason you come to our store, you are missing out on the greatest shopping experience of your life. The next time you have some time to spare, come on in and browse around your nearest Home Depot. You just may be surprised at what you?ve been missing. One thing is certain, you will not regret looking around the #1 home improvement retailer. You?re going to love Home Depot.

Source: http://www.faridadjazairi.com/look-no-further-than-home-depot-for-appliances-all-your-home-appliances-in-one-place.html

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Sect bombs a checkpoint in Nigeria's northeast (AP)

MAIDUGURI, Nigeria ? Authorities say suspected sect members have detonated a bomb near a checkpoint in Nigeria's restive northeast.

Lt. Col. Hassan Mohammed says assailants from the Boko Haram sect set off a bomb Tuesday in the city of Maiduguri. He says there were no casualties.

An Associated Press reporter who was in the area said residents locked themselves indoors after soldiers started shooting in the air in search of the bomber.

Boko Haram is responsible for a rash of killings targeting security officers, local leaders and clerics. It is also blamed for a series of deadly blasts.

The government on Tuesday formed a committee in Abuja to find solutions to combat the threat posed by the Islamic militants who seek the strict implementation of Shariah law across the Muslim-dominated north.

Source: http://us.rd.yahoo.com/dailynews/rss/africa/*http%3A//news.yahoo.com/s/ap/20110802/ap_on_re_af/af_nigeria_violence

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Cat Bunk Bed & Playroom: The World of Bootsie | Pets Trends

cat-bed-playroom-bootsie

Our kittens need a place to play and sleep, so why not combine the two together? Bootsie?s Bunk Bed and Playroom is the perfect solution for cat owners. Not only is it gorgeous and adorable, but also functional for both you and your cat.

This sturdy wood structure serves as a fully functional playhouse. The Velcro perimeter on the underside of the sisal covering attaches firmly in place and the whole unit then slides easily onto the playroom frame. That?s not all, The handy roof accessory provides Kitty with yet another healthy and popular feline activity ? scratching. This setup has got it all ? Welcome to the world of Bootsie.

Any living creature is the happiest when its basic needs are satisfied. This one goes for humans as well as our pets. This charming set makes sure that your cat?s basic needs are addressed at all times, which keeps you worry-free.

cat-bed-playroom-bootsie-1

Once you get the entire package with the optional roof, you can be sure all your cats are happy and calm. This is an easily assembled unit that attaches firmly to the Bunk Bed and Playroom with heavy-duty plastic brackets, so there?s no worry whatsoever. It?s high time your cats will get their own playroom?

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Source: http://www.petstrends.com/2011/08/03/cat-bed-playroom-bootsie/

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Plywood Boat Building ? Our Techniques to Building a Solid Boat ...

Particle board fishing boat building is a great interest which makes any gratifying example of your current free time.

An interest is a thing that certain loves carrying out at the very least and yes it normally calls for some time and determination. It doesn?t matter self-assured in your amassing stamps as well as in case you draw whenever you have the situation. It?s something innovative along with pleasant in most hobbies and interests provide that will sense of good results. But the most effective hobbies and interests could be the pleasure of performing issues on your own.

Building issues things issues items sewing your own clothes producing your individual necklaces locks face masks and the like is incredibly satisfying and those that possess a gift pertaining to undertaking items like this by themselves have a good time while in internet marketing.

If you live the person who normally buys concluded items that doesn?t suggest that you simply cannot make different. In case your hobby can be boats as well as fishing then you can incorporate this specific using the enjoyment to build your personal plyboard boat. Nearly every homemade vessel is a particle board fishing boat since plywood is practically usually found in constructing watercraft specially by people who are constructing these theirself.

Naturally for starting up particle board boat constructing you will want plywood much more exactly a pair of bedding than it.

You?ll likely certainly not discover the required supplies as pricey because buying a great already-made tiny vessel so it?s worth every penny. Even more when compared with that will big t you may be developing one thing you?re keen on which will make the idea 2 times a lot more special compared to a boat you simply obtain the shop. You are doing require all of the needed resources yet almost everything can be nothing at all without correct fishing boat plans that you may have to follow along with.

Purchase a lure found if you don?t curently have 1 plus a routine as well. Another essential portion of building this can be the pencil because you will have to measure every little thing mark along with match up to be sure that you will not receive an asymmetric motorboat. Stick stick is also critical since you will certainly put it to use on each of the solid wood components in a very solid layer when you blend it with the saw airborne debris you?ve. One particular quart associated with stick and something handbag of observed dust must do it. Do not forget regarding receiving 2 found race horses while they may be the support of the fishing boat this complete occasion.

You will have to put abs plastic cloth about the comes and have it fully moist together with adhesive. Plastic-type jewelry will be needed too along with sand paper will help you easy the particular motorboat as soon as it can be finished. After things are all sleek you are able to coloring the actual motorboat.

A lot of people just like the colour since it is so they only varnish that nevertheless this is just reliant on tastes thus choose your preferred. Now that you?ve learned all you may need with regard to developing your own personal particle board motorboat however you also have to discover how to do it all to be able to set items jointly r.

It?s always safer to purchase some good boat constructing recommendations for security reasons. Some individuals also favor conversing with a professional prior to starting to develop items on their own in case you might be a handy man or woman you will subsequently be okay using the fishing boat ideas and also the instructions.

Please visit at Plywood boat building & Small boat building

Source: http://www.writerfriend.com/recreation-sports/plywood-boat-building-our-techniques-to-building-a-solid-boat/

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